>> Home >> Dr. Manojkumar Bhat

Manoj Kumar Bhat, Ph.D.

Scientist 'G' , Laboratory No. 6
National Centre for Cell Science
NCCS Complex, Pune University Campus
Ganeshkhind, PUNE- 411 007, INDIA
Ph.: +91-020-25708066/25708000
Fax: +91-020-25692259
E-mail: manojkbhat@nccs.res.in ; manojkbhat@yahoo.com
Webpage: http://www.nccs.res.in/mkbhat.html


Education | Area of Research | Recent Publications | Lab Alumni | Lab Members






Ph.D. Biochemistry, 1992, University of Mysore, India

M.Sc. Biochemistry, 1985, University of Mysore, India

B.Sc. Chemistry, Physics and Mathematics, 1983, University of Mysore, India




Fellow, National Academy of Sciences, India, 2011

Indian Association for Cancer Research

Indian Society of Cell Biology



Area of Research

Cell Biology and Cancer Biology/Chemotherapy

  • Recent studies have suggested that metabolic disorders like diabetes and obesity alter the risk of developing variety of cancers, and the associations are biologically plausible. With the hypothesis that nutrient availability and insulin signaling pathways are linked to cell proliferation and survival, a greater understanding of the relationship between diabetes/obesity and cancer will lead to innovative avenues of pharmaceutical investigation.

  • The medical need for advances in cancer treatment with surgery, radiotherapy and conventional cytotoxic chemotherapy, have made only a modest overall impact on mortality. Hence the significance of discovering new targets, pathways and strategies for therapeutic intervention in cancer is extremely important. Therefore, understanding the molecular events that contribute or enhance drugs induced cell death will not only help in explaining the relationship between cancer genetics and chemotherapeutic drugs but also will improve sensitivity as well as specificity of the treatment.



Recent Publications

  • Ajay, A.K., Meena A.S. and Bhat M.K.: Human papillomavirus 18 E6 inhibits phosphorylation of overexpressed p53 in HeLa cells. Cell and Bioscience, 2:2 (2012).

  • Vijayakumar, M.V. and Bhat, M.K.: Real Time Qualitative and Quantitative GLUT4 Translocation Assay. Methods Enzymol, 505:257-71, (2012).

  • Sharma, A. and Bhat M.K.: Enhancement of Carboplatin and Quercetin Induced Cell Death by Roscovitine is Akt Dependent and p53 Independent in Hepatoma Cells. Integrated Cancer Therapies, 10 (4), (2011).

  • Pandey V., Chaube, B. and Bhat M.K.: Hyperglycemia regulates MDR-1, drug uptake and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. Journal of Cellular Biochemistry, 112:2942-2952 (2011).

  • Kumar, A., Chinta, J.P., Ajay, A.K., Bhat M.K. and Rao, C.P.: Synthesis, characterization, plasmid cleavage and cytotoxicity of cancer cells by a copper(II) complex of anthracenyl-terpyridine. Dalton Transactions, 40, 10865-10872, (2011).

  • Pandey V., Vijayakumar, M.V., Ajay, A.K. Malvi, P. and Bhat M.K.: Diet induced obesity increases melanoma progression: involvement of Cav-1 and FASN. International Journal of Cancer, 130(3):497-508, (2012).

  • Vijayakumar, M.V., Ajay, A.K. and Bhat M.K.: Demonstration of a visual cell-based assay for screening glucose transporter 4 translocation modulators in real time. Journal of Biosciences, 35(4):525-531, (2010).

  • Ajay, A.K, Upadhyay, A.K., Singh S., Vijayakumar, M.V., Kumari, R., Pandey, V., Boppana, R. and Bhat M.K.: Cdk5 Phosphorylates Non-genotoxically Overexpressed p53 following Inhibition of PP2A to Induce Cell Cycle Arrest/apoptosis and Inhibits Tumor Progression. Molecular Cancer, 9: 204, (2010).

  • Sharma, A. Meena A.S. and Bhat M.K.: Hyperthermia associated carboplatin resistance: Differential role of p53, HSF1 and Hsp70 in hepatoma Cells. Cancer Science, 101(5):1186-1193, (2010).

  • Shriram, V., Kumar, V., Suryawanshi, S., Upadhyay, A. and Bhat M.K.: Cytotoxic activity of 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol from Eulophia nuda against human cancer cells. Journal of Ethnopharmacology, 28(1):251-253, (2010).

  • Vijayakumar, M.V., Pande, V, Mishra, G.C. and Bhat M.K.: Hypolipidemic effect of fenugreek seeds is mediated through inhibition of fat accumulation and up regulation of LDL receptor. Obesity, 18(4):667-674, (2010).


Complete Article Listing



Book Chapter


An invited article titled Strategy to develop new drugs Diabetes and Identification of new targets among the signaling path in the development of Diabetes by Maleppillil Vavachan Vijayakumar and Manoj Kumar Bhat, has been published in books entitled: Chronic Inflammatory Diseases and Nutraceuticals (Molecular Mechanism of Chronic Diseases, New Targets & Drugs and Basic Concept of Ayurveda). Edited by Yamini B. Tripathi, Pages 257-266, (2005).



Lab Alumni

  • Dr. Rishi Raj Chippa (2007)

    Present address: Postdoctoral Fellow

    Roswell Park Cancer Institute, Buffalo, NY-14263, USA

    Email:rishi.chippa@roswellpark.org ; rishi.chippa@yahoo.com


  • Dr. Sandeep Singh (2007)

    Present address: Assistant Professor

    National Institute of Biomedical Genomics, Kalyani 741251 WB India

    Email: sandeepsingh@yahoo.com; sandeep.singh.res@gmail.com ; SS5@nibmg.ac.in


  • Dr. Ankur Kumar Upadhyay (2008)

    Present address: Research Scientist

    Pharmacology Division, New Drug Discovery Research (NDDR),
    Ranbaxy Laboratories Ltd, Sector 18, Plot 20, Udyog Vihar Industrial Area, Gurgaon, Haryana 122001, India

    Email: ankurnccs@yahoo.co.in;ankur.kumar.fi@dsin.co.in 


  • Dr. Maleppillil Vavachan Vijayakumar (2010)

    Present address:National Centre for Cell Science, Pune

    Email: vijayk@nccs.res.in;vkumar20@yahoo.com


  • Dr. Amrendra Kumar Ajay (2010)

    Present address: Postdoctoral Fellow

    Harvard Medical School Brigham and Women's Hospital, Boston, MA 02115.

    Email: akajay21g@yahoo.com


  • Dr. Vimal Pandey (2011)

    Present address: Research Associate

    Cell death and cell survival group, Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad - 500 001

    Email: vimal_2808@yahoo.com;vimpsine@rediff.com


  • Dr. Aanchal Sharma (2011)

    Present address: Research Scientist

    Ranbaxy Laboratories Ltd, Sector 18, Plot 20, Udyog Vihar Industrial Area, Gurgaon, Haryana 122001, India

    Email: aanchal97@gmail.com;aanchal_india@rediffmail.com


  • Mrs. Ratna Kumari. Submitted thesis for the award of Ph.D degree in Biotechnology, University of Pune, April 2010

    Present address: Postdoctoral Fellow

    Department of Orthopaedic Surgery, U.C. Davis Medical Center, 4635 2nd Ave. Sacramento, CA 95817.

    Email: rkumari@ucdavis.edu ; ratnabt@yahoo.com 




Present Lab Members




Mr. Vijayakumar M.V.
Technical officer B
(1999 to present)


Avtar Singh Meena
(2008 to present)


Parmanand Malvi
(2009 to present)


Balkrishna Chaube
(2009 to present)


Naoshad Mohammad
(2010 to present)
naishrath97@gmail.com naishrath97@yahoo.com


Shivendra Vikarm Singh
(2010 to present)


Surbhi Chouhan
(2011 to present)


Snahlata Singh
(2011 to present)






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NCCS Complex,University of Pune Campus,Ganeshkhind,Pune 411007,Maharashtra,India Phone: +91-20-25708000 Fax:+91-20-25692259 Gram:ATCELL