Deepa Subramanyam


Our lab is interested in aspects of cellular trafficking that differ between embryonic stem cells and differentiated cells. We are primarily focusing on the role of endocytosis in cell fate determination. This work is important in embryonic stem cell development and for understanding early mammalian development.


Education

Phd : National Centre for Biological Sciences,TIFR, Bangalore - 2006.

BSc : PSG College of Arts and Science, Coimbatore - 1999.


Research Experience

Scientist D - National Centre for Cell Science, Pune - 2012 November to present.

Postdoctoral Fellow - University of California at San Francisco - 2006 - 2012.


Funding

Wellcome Trust –DBT India Alliance Intermediate Fellowship.

NCCS Intramural funds.


Opportunities

We are looking for highly motivated individuals interested in stem cell biology and early development. If you feel our science excites you, please send an email to deepa@nccs.res.in with your updated CV containing the names of three references along with a statement of purpose. We have a number of vacant positions for graduate students who have their own fellowships. Posts are also available for individuals interested in pursuing their postdoctoral training, who have their own source of funding.


Collaborators

Raghav Rajan, IISER, Pune


Select Publications

  1. Deepa Subramanyam*. Cellular reprogramming – Turning the clock back. Resonance, June 2013; 514-521.

  2. Yangming Wang, Collin Melton, Ya-Pu Li, Archana Shenoy, Xin-Xin Zhang, Deepa Subramanyam and Robert Blelloch. MiR-294/miR-302 family promotes proliferation, suppresses the G1-S restriction point, and inhibits embryonic stem cell differentiation through separable mechanisms. Cell Reports, 2013; 4(1): 99-109.

  3. Samy Lamouille, Deepa Subramanyam, Rik Derynck and Robert Blelloch. Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs. Current Opinion in Cell Biology, 2013; 25(2) : 200-7.

  4. Devanand S. Manoli, Deepa Subramanyam, Catriona Carey, Julie A. Van Westerhuyzen, Karen L. Bales, Robert Blelloch and Nirao M. Shah. Generation of induced pluripotent stem cells from the Prairie vole. PLoS One, 2012; 7(5):e38119.

  5. Deepa Subramanyam, Samy Lamouille, Robert L. Judson, Jason Y. Liu, Nathan Bucay, Rik Derynck and Robert Blelloch. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nature Biotechnology, 2011 May;29(5):443-8.

  6. Deepa Subramanyam and Robert Blelloch. From microRNAs to targets: pathway discovery in cell fate transitions. Review. Current Opinion in Genetics and Development, 2011 Aug; 21(4):498-503.

  7. Jeevisha Bajaj, Tessy T. Maliekal, Eric Vivien, Chitra Pattabiraman, Sweta Srivastava, H. Krishnamurthy, G. V. Giri, Deepa Subramanyam and Sudhir Krishna. Notch signaling in CD66+ cells drives the progression of human cervical cancers. Cancer Research, 2011; Jul 15;71(14):4888-97

  8. Hamed Al-Hussaini, Deepa Subramanyam, Michael Reedijk and Srikala Sridhar. Notch Signaling Pathway as a Therapeutic Target in Breast Cancer. Molecular Cancer Therapeutics, 2011 Jan;10(1):9-15.

  9. Deepa Subramanyam, Cassandra D. Belair, Keegan Q. Barry-Holson, Haijiang Lin, Scott C. Kogan, Emmanuelle Passegué, and Robert Blelloch. PML-RARα and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Research, 2010; Nov 1;70(21):8792-801.

  10. Suruchi Mittal, Deepa Subramanyam, Devaveena Dey, Rekha V Kumar and Annapoorni Rangarajan. Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis. Molecular Cancer, 2009 Dec 23;8(1):128.

  11. Deepa Subramanyam and Robert Blelloch. Watching reprogramming in real time. Nature Biotechnology, 2009, Nov;27(11):997-8.

  12. Tessy T. Maliekal, Jeevisha Bajaj , V. Giri, Deepa Subramanyam, Sudhir Krishna. The role of Notch signaling in human cervical cancer: implications for solid tumors. Oncogene, 2008 Sep 1;27(38):5110-4.

  13. Deepa Subramanyam* and Sudhir Krishna. c-Myc substitutes for Notch1-CBF1 functions in cooperative transformation with papillomavirus oncogenes. Virology, 2006 Mar 30;347(1):191-8.

  14. Deepa Subramanyam*. Asymmetry Pins Inscuteable. Current Science, 2000 August 10; 79(3): 271-3.


*Corresponding author.

 For a complete list of publications go to: http://www.ncbi.nlm.nih.gov/pubmed/?term=Deepa+Subramanyam

 

Lab webpage

Deepa Laboratory


Email

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